- Full Name: Qutlugh Nigar Khanum
- Born: Not known
- Died: 10th June 1505
- Tenure: 1475 to 1492
- Religion: Islam
- Dynasty: House of Borjigin (by birth) | House of Timur (by marriage)
- Spouse: Umar Shaikh Mirza II
- Father: Yunus Khan
- Mother: Aisan Daulat Begum
- Famous as: Queen consort of Ferghana Valley
Qutlugh Nigar Khanum (also spelled Kutlak Nigar Khanum) was the first wife and chief consort of Umar Shaikh Mirza II, the ruler of Ferghana Valley. She was a princess of Moghulistan by birth. She was also the daughter of Yunus Khan who was known as the Great Khan of Moghulistan.
She was also the mother of Emperor Babur, the founder of the Mughal Empire of India.